|
| Issue 1292-5 |
| US 6,872,558 B1 |
| Heparanase-2 a member of the heparanase protein family |
| Klaus Dücker, Darmstadt (Germany); and Christian Sirrenberg, Darmstadt (Germany) |
| Assigned to Merck Patent GmbH, Darmstadt (Germany) |
| Appl. No. 10/88,676 PCT Filed Sep. 11, 2000, PCT No. PCT/EP00/08837 § 371(c)(1), (2), (4) Date Mar. 21, 2002, PCT Pub. No. WO01/21814, PCT Pub. Date Mar. 29, 2001. |
| Claims priority of application No. 99118805 (EP), filed on Sep. 23, 1999; and application No. 00114649 (EP), filed on Jul. 07, 2000. |
| Int. Cl.7C12N 9/00 |
| U.S. Cl. 435—200 [435/4; 435/6; 435/69.1; 435/183; 435/192; 435/252.3; 435/320.1; 435/325; 536/23.2; 536/23.4; 536/23.5; 530/350] | 16 Claims |
| 1. An isolated polypeptide which is:
(a) an isolated polypeptide encoded by a polynucleotide comprising the sequence of SEQ ID NO:1;
(b) an isolated polypeptide comprising a polypeptide sequence having at least 95% identity to the polypeptide sequence of
SEQ ID NO:2; or
(c) an isolated polypeptide having at least 95% identity to the polypeptide sequence of SEQ ID NO:2 wherein said polypeptide
has heparanase activity.
|